An SH3PX1-dependent endocytosis/autophagy network restrains intestinal stem cell proliferation by counteracting EGFR/ERK signaling

The effect of intracellular vesicle trafficking on stem cell behavior is largely unexplored. We screened the Drosophila sorting nexins (SNXs) and discovered that one, SH3PX1, profoundly affects gut homeostasis and lifespan. SH3PX1 restrains intestinal stem cell (ISC) division through an endocytosis/...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Dev Cell
Main Authors: Zhang, Peng, Holowatyj, Andreana N., Roy, Taylor, Pronovost, Stephen M., Marchetti, Marco, Liu, Hanbin, Ulrich, Cornelia M., Edgar, Bruce A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542281/
https://ncbi.nlm.nih.gov/pubmed/31006650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.03.029
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