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An SH3PX1-dependent endocytosis/autophagy network restrains intestinal stem cell proliferation by counteracting EGFR/ERK signaling
The effect of intracellular vesicle trafficking on stem cell behavior is largely unexplored. We screened the Drosophila sorting nexins (SNXs) and discovered that one, SH3PX1, profoundly affects gut homeostasis and lifespan. SH3PX1 restrains intestinal stem cell (ISC) division through an endocytosis/...
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| Publicado no: | Dev Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6542281/ https://ncbi.nlm.nih.gov/pubmed/31006650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.03.029 |
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