A kindred with Mutant IKAROS and autoimmunity.

IKAROS (encoded by IKZF1) is an important hematopoietic transcription factor critical for early B cell differentiation, with major defects known to lead to low B cell numbers and hypogammaglobulinemia. More perplexing is the link between IKZF1 variants and autoimmunity, including polymorphisms assoc...

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Détails bibliographiques
Publié dans:J Allergy Clin Immunol
Auteurs principaux: Van Nieuwenhove, Erika, Garcia-Perez, Josselyn E., Helsen, Christine, Rodriguez, Princess D., van Schouwenburg, Pauline A., Dooley, James, Schlenner, Susan, van der Burg, Mirjam, Verhoeyen, Els, Gijsbers, Rik, Frietze, Seth, Schjerven, Hilde, Meyts, Isabelle, Claessens, Frank, Humblet-Baron, Stephanie, Wouters, Carine, Liston, Adrian
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541477/
https://ncbi.nlm.nih.gov/pubmed/29705243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.04.008
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