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Obstacles to scanning by RNase E govern bacterial mRNA lifetimes by hindering access to distal cleavage sites

The diversity of mRNA lifetimes in bacterial cells is difficult to reconcile with the relaxed cleavage-site specificity of RNase E, the endonuclease most important for governing mRNA degradation. This enzyme has generally been thought to locate cleavage sites by searching freely in three dimensions....

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Pubblicato in:Mol Cell
Autori principali: Richards, Jamie, Belasco, Joel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541411/
https://ncbi.nlm.nih.gov/pubmed/30852060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.044
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