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Restoration of susceptibility to amikacin by 8-hydroxyquinoline analogs complexed to zinc
Gram-negative pathogens resistant to amikacin and other aminoglycosides of clinical relevance usually harbor the 6’-N-acetyltransferase type Ib [AAC(6')-Ib], an enzyme that catalyzes inactivation of the antibiotic by acetylation using acetyl-CoA as donor substrate. Inhibition of the acetylating...
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| 出版年: | PLoS One |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6541283/ https://ncbi.nlm.nih.gov/pubmed/31141575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217602 |
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