Restoration of susceptibility to amikacin by 8-hydroxyquinoline analogs complexed to zinc

Gram-negative pathogens resistant to amikacin and other aminoglycosides of clinical relevance usually harbor the 6’-N-acetyltransferase type Ib [AAC(6')-Ib], an enzyme that catalyzes inactivation of the antibiotic by acetylation using acetyl-CoA as donor substrate. Inhibition of the acetylating...

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Udgivet i:PLoS One
Main Authors: Magallon, Jesus, Chiem, Kevin, Tran, Tung, Ramirez, Maria S., Jimenez, Veronica, Tolmasky, Marcelo E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541283/
https://ncbi.nlm.nih.gov/pubmed/31141575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217602
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