Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B

Background: KDM5 enzymes are H3K4 specific histone demethylases involved in transcriptional regulation and DNA repair. These proteins are overexpressed in different kinds of cancer, including breast, prostate and bladder carcinomas, with positive effects on cancer proliferation and chemoresistance....

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Pippa, Simone, Mannironi, Cecilia, Licursi, Valerio, Bombardi, Luca, Colotti, Gianni, Cundari, Enrico, Mollica, Adriano, Coluccia, Antonio, Naccarato, Valentina, La Regina, Giuseppe, Silvestri, Romano, Negri, Rodolfo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540222/
https://ncbi.nlm.nih.gov/pubmed/31060229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24091739
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