An High-Throughput In Vivo Screening System to Select H3K4-Specific Histone Demethylase Inhibitors

BACKGROUND: Histone demethylases (HDMs) have a prominent role in epigenetic regulation and are emerging as potential therapeutic cancer targets. The search for small molecules able to inhibit HDMs in vivo is very active but at the present few compounds were found to be specific for defined classes o...

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Bibliographic Details
Main Authors: Mannironi, Cecilia, Proietto, Marco, Bufalieri, Francesca, Cundari, Enrico, Alagia, Angela, Danovska, Svetlana, Rinaldi, Teresa, Famiglini, Valeria, Coluccia, Antonio, La Regina, Giuseppe, Silvestri, Romano, Negri, Rodolfo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906020/
https://ncbi.nlm.nih.gov/pubmed/24489688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086002
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