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Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine
Engineering aminoacyl-tRNA synthetases (aaRSs) provides access to the ribosomal incorporation of noncanonical amino acids via genetic code expansion. Conventional targeted mutagenesis libraries with 5–7 positions randomized cover only marginal fractions of the vast sequence space formed by up to 30...
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| Publicado no: | Int J Mol Sci |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6539999/ https://ncbi.nlm.nih.gov/pubmed/31083552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20092343 |
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