The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2

Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer fam...

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Vydáno v:Protein Cell
Hlavní autoři: Wang, Xinhui, Gao, Hong, Wu, Wenhui, Xie, Enjun, Yu, Yingying, He, Xuyan, Li, Jin, Zheng, Wanru, Wang, Xudong, Cao, Xizhi, Meng, Zhuoxian, Chen, Ligong, Min, Junxia, Wang, Fudi
Médium: Artigo
Jazyk:Inglês
Vydáno: Higher Education Press 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538592/
https://ncbi.nlm.nih.gov/pubmed/30324491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-018-0580-1
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