Disruption of embryonic ROCK signaling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy

Sarcomeric disarray is a hallmark of gene mutations in patients with hypertrophic cardiomyopathy (HCM). However, it is unknown when detrimental sarcomeric changes first occur and whether they originate in the developing embryonic heart. Furthermore, Rho kinase (ROCK) is a serine/threonine protein ki...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Bailey, Kate E., MacGowan, Guy A., Tual-Chalot, Simon, Phillips, Lauren, Mohun, Timothy J., Henderson, Deborah J., Arthur, Helen M., Bamforth, Simon D., Phillips, Helen M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2019
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538384/
https://ncbi.nlm.nih.gov/pubmed/30835717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125172
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