An order-to-disorder structural switch activates the FoxM1 transcription factor

Intrinsically disordered transcription factor transactivation domains (TADs) function through structural plasticity, adopting ordered conformations when bound to transcriptional co-regulators. Many transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of transc...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Marceau, Aimee H, Brison, Caileen M, Nerli, Santrupti, Arsenault, Heather E, McShan, Andrew C, Chen, Eefei, Lee, Hsiau-Wei, Benanti, Jennifer A, Sgourakis, Nikolaos G, Rubin, Seth M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538375/
https://ncbi.nlm.nih.gov/pubmed/31134895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46131
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