Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis

Extracellular mRNAs (ex-mRNAs) potentially supersede extracellular miRNAs (ex-miRNAs) and other RNA classes as biomarkers. We performed conventional small-RNA-sequencing (sRNA-seq) and sRNA-seq with T4 polynucleotide kinase (PNK) end treatment of total extracellular RNAs (exRNAs) isolated from serum...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Akat, Kemal M., Lee, Youngmin A., Hurley, Arlene, Morozov, Pavel, Max, Klaas E.A., Brown, Miguel, Bogardus, Kimberly, Sopeyin, Anuoluwapo, Hildner, Kai, Diacovo, Thomas G., Neurath, Markus F., Borggrefe, Martin, Tuschl, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
Soggetti:
Technical Advance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538341/
https://ncbi.nlm.nih.gov/pubmed/30973829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127317
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