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Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry

Recombinant adeno-associated viruses (AAVs) are promising vectors for human gene therapy. However, current methods for evaluating AAV particle populations and vector purity are inefficient and low resolution. Here, we show that charge detection mass spectrometry (CDMS) can resolve capsids that conta...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Pierson, Elizabeth E., Keifer, David. Z., Asokan, Aravind, Jarrold, Martin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537880/
https://ncbi.nlm.nih.gov/pubmed/27310298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b00883
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