Association of Patisiran, an RNA Interference Therapeutic, With Regional Left Ventricular Myocardial Strain in Hereditary Transthyretin Amyloidosis: The APOLLO Study

IMPORTANCE: Patients with cardiac amyloidosis demonstrate reduced myocardial strain with associated sparing of the cardiac apex. In the APOLLO randomized clinical trial, patisiran, an RNA interference therapeutic that inhibits transthyretin synthesis, improved left ventricular (LV) global longitudin...

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Detalhes bibliográficos
Publicado no:JAMA Cardiol
Main Authors: Minamisawa, Masatoshi, Claggett, Brian, Adams, David, Kristen, Arnt V., Merlini, Giampaolo, Slama, Michel S., Dispenzieri, Angela, Shah, Amil M., Falk, Rodney H., Karsten, Verena, Sweetser, Marianne T., Chen, Jihong, Riese, Richard, Vest, John, Solomon, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537803/
https://ncbi.nlm.nih.gov/pubmed/30878017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2019.0849
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