Association of Patisiran, an RNA Interference Therapeutic, With Regional Left Ventricular Myocardial Strain in Hereditary Transthyretin Amyloidosis: The APOLLO Study

IMPORTANCE: Patients with cardiac amyloidosis demonstrate reduced myocardial strain with associated sparing of the cardiac apex. In the APOLLO randomized clinical trial, patisiran, an RNA interference therapeutic that inhibits transthyretin synthesis, improved left ventricular (LV) global longitudin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JAMA Cardiol
Prif Awduron: Minamisawa, Masatoshi, Claggett, Brian, Adams, David, Kristen, Arnt V., Merlini, Giampaolo, Slama, Michel S., Dispenzieri, Angela, Shah, Amil M., Falk, Rodney H., Karsten, Verena, Sweetser, Marianne T., Chen, Jihong, Riese, Richard, Vest, John, Solomon, Scott D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Medical Association 2019
Pynciau:
Brief Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537803/
https://ncbi.nlm.nih.gov/pubmed/30878017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2019.0849
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