Association of Patisiran, an RNA Interference Therapeutic, With Regional Left Ventricular Myocardial Strain in Hereditary Transthyretin Amyloidosis: The APOLLO Study

IMPORTANCE: Patients with cardiac amyloidosis demonstrate reduced myocardial strain with associated sparing of the cardiac apex. In the APOLLO randomized clinical trial, patisiran, an RNA interference therapeutic that inhibits transthyretin synthesis, improved left ventricular (LV) global longitudin...

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Veröffentlicht in:JAMA Cardiol
Hauptverfasser: Minamisawa, Masatoshi, Claggett, Brian, Adams, David, Kristen, Arnt V., Merlini, Giampaolo, Slama, Michel S., Dispenzieri, Angela, Shah, Amil M., Falk, Rodney H., Karsten, Verena, Sweetser, Marianne T., Chen, Jihong, Riese, Richard, Vest, John, Solomon, Scott D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Medical Association 2019
Schlagworte:
Brief Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537803/
https://ncbi.nlm.nih.gov/pubmed/30878017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2019.0849
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