Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4(+) T lymphocyte activation

BACKGROUND: The protein kinase C theta (PKCθ) has an important and non-redundant function downstream of the antigen receptor and co-receptor complex in T lymphocytes. PKCθ is not only essential for activation of NF-κB, AP-1 and NFAT and subsequent interleukin-2 expression, but also critical for posi...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Commun Signal
Hauptverfasser: Siegmund, Kerstin, Thuille, Nikolaus, Posch, Nina, Fresser, Friedrich, Leitges, Michael, Baier, Gottfried
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Short Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537413/
https://ncbi.nlm.nih.gov/pubmed/31138259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0364-0
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