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Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4(+) T lymphocyte activation
BACKGROUND: The protein kinase C theta (PKCθ) has an important and non-redundant function downstream of the antigen receptor and co-receptor complex in T lymphocytes. PKCθ is not only essential for activation of NF-κB, AP-1 and NFAT and subsequent interleukin-2 expression, but also critical for posi...
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| Izdano u: | Cell Commun Signal |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6537413/ https://ncbi.nlm.nih.gov/pubmed/31138259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0364-0 |
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