Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts

Background: Cardiopulmonary bypass (CPB) applied during coronary artery bypass grafting (CABG), promotes inflammation, generation of reactive oxygen species (ROS) and up-regulation of matrix metalloproteinases (MMPs). All these complications may lead to contractile dysfunction, restenosis and early...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Saeed, Mazen, Arun, Mehmet Zuhuri, Guzeloglu, Mehmet, Onursal, Ceylan, Gokce, Goksel, Korkmaz, Ceren Gonen, Reel, Buket
Format: Artigo
Language:Inglês
Published: Dove 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536710/
https://ncbi.nlm.nih.gov/pubmed/31213768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S187842
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