Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy

OBJECTIVE: Intradiscal biologic therapy is a promising strategy for managing intervertebral disc degeneration. However, these therapies require a rich nutrient supply, which may be limited by the transport properties of the cartilage endplate (CEP). This study investigated how fluctuations in CEP tr...

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Veröffentlicht in:Osteoarthritis Cartilage
Hauptverfasser: Wong, Jason, Sampson, Sara L., Bell-Briones, Hildegarde, Ouyang, Ann, Lazar, Ann A., Lotz, Jeffrey C., Fields, Aaron J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536352/
https://ncbi.nlm.nih.gov/pubmed/30721733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2019.01.013
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