Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition

Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies. Here we demonstrate that treating the CEP with matrix metalloproteinase-8 (MMP-8) reduces the matrix constituents that impede solute...

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Udgivet i:PLoS One
Main Authors: Dolor, Aaron, Sampson, Sara L., Lazar, Ann A., Lotz, Jeffrey C., Szoka, Francis C., Fields, Aaron J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457523/
https://ncbi.nlm.nih.gov/pubmed/30970007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215218
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