Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy

OBJECTIVE: Hypoxia is central in the pathogenesis of diabetic retinopathy (DR). Hypoxia-inducible factor-1 (HIF-1) is the key mediator in cellular oxygen homeostasis that facilitates the adaptation to hypoxia. HIF-1 is repressed by hyperglycemia contributing by this to the development of complicatio...

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Publicat a:J Diabetes Res
Autors principals: Ekberg, Neda Rajamand, Eliasson, Sofie, Li, Young Wen, Zheng, Xiaowei, Chatzidionysiou, Katerina, Falhammar, Henrik, Gu, Harvest F., Catrina, Sergiu-Bogdan
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535890/
https://ncbi.nlm.nih.gov/pubmed/31214621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2936962
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