Broad-Spectrum Proteome Editing with an Engineered Bacterial Ubiquitin Ligase Mimic

[Image: see text] Manipulation of the ubiquitin-proteasome pathway to achieve targeted silencing of cellular proteins has emerged as a reliable and customizable strategy for remodeling the mammalian proteome. One such approach involves engineering bifunctional proteins called ubiquibodies that are c...

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Publicat a:ACS Cent Sci
Autors principals: Ludwicki, Morgan B., Li, Jiahe, Stephens, Erin A., Roberts, Richard W., Koide, Shohei, Hammond, Paula T., DeLisa, Matthew P.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535771/
https://ncbi.nlm.nih.gov/pubmed/31139721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b00127
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