Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide

Pyrazinamide (PZA) is a unique frontline drug for shortening tuberculosis (TB) treatment, but its mechanisms of action are elusive. We previously found one PZA-resistant strain that harbors an alanine deletion at position 438 (Δ438A) in RpsA, a target of PZA associated with PZA resistance, but its r...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Shi, Wanliang, Cui, Peng, Niu, Hongxia, Zhang, Shuo, Tønjum, Tone, Zhu, Bingdong, Zhang, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535565/
https://ncbi.nlm.nih.gov/pubmed/30858213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02681-18
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