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Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disrupts the ribosome rescue process of trans-translation in Mycobacterium tuberculosis. This model suggested th...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5522395/ https://ncbi.nlm.nih.gov/pubmed/28733601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06415-5 |
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