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Tolerance to WIN55,212-2 is delayed in desensitization-resistant S426A/S430A mice
Tolerance to cannabinoid agonists can develop through desensitization of the cannabinoid receptor 1 (CB(1)) following prolonged administration. Desensitization results from phosphorylation of CB(1) by a G protein-coupled receptor kinase (GRK), and subsequent association of the receptor with arrestin...
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| Publicado en: | Neuropharmacology |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6535342/ https://ncbi.nlm.nih.gov/pubmed/30629988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2018.12.026 |
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