Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.

1. Mice pretreated intraperitoneally for 2 days with delta-9-tetrahydrocannabinol (delta-9-THC) at a dose of 20 mg kg-1 day-1 and then challenged intravenously with this drug, 24 h after the second pretreatment, showed a 6 fold tolerance to the hypothermic effect of delta-9-THC. This pretreatment al...

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Main Authors: Pertwee, R. G., Stevenson, L. A., Griffin, G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175863/
https://ncbi.nlm.nih.gov/pubmed/8306090
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