PKCε Regulates Behavioral Sensitivity, Binding and Tolerance to the CB1 Receptor Agonist WIN55,212-2

The cannabinoid CB1 receptor (CB1) is one of the most abundant G protein-coupled receptors in the brain, but little is known about the mechanisms that modulate CB1 receptor signaling. Here we show that inhibition or null mutation of the epsilon isozyme of protein kinase C (PKCε) selectively enhances...

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Bibliographic Details
Main Authors: Wallace, Melisa J., Newton, Philip M., McMahon, Thomas, Connolly, Jacklyn, Huibers, Anne, Whistler, Jennifer, Messing, Robert O.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680927/
https://ncbi.nlm.nih.gov/pubmed/19158669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2008.230
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