Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells

The spatial organization of chromatin is pivotal for regulating genome functions. We report an imaging method for tracing chromatin organization with kilobase- and nanometer-scale resolution, unveiling chromatin conformation across topologically associating domains (TADs) in thousands of individual...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Bintu, Bogdan, Mateo, Leslie J., Su, Jun-Han, Sinnott-Armstrong, Nicholas A., Parker, Mirae, Kinrot, Seon, Yamaya, Kei, Boettiger, Alistair N., Zhuang, Xiaowei
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535145/
https://ncbi.nlm.nih.gov/pubmed/30361340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau1783
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