Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells

A major obstacle to curing chronic myeloid leukemia (CML) is the intrinsic resistance of CML stem cells (CMLSCs) to the drug imatinib mesylate (IM). Prosurvival genes that are preferentially expressed in CMLSCs compared with normal hematopoietic stem cells (HSCs) represent potential therapeutic targ...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ma, Leyuan, Pak, Magnolia L., Ou, Jianhong, Yu, Jun, St. Louis, Pamela, Shan, Yi, Hutchinson, Lloyd, Li, Shaoguang, Brehm, Michael A., Zhu, Lihua Julie, Green, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535024/
https://ncbi.nlm.nih.gov/pubmed/31068472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903550116
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