Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells

A major obstacle to curing chronic myeloid leukemia (CML) is the intrinsic resistance of CML stem cells (CMLSCs) to the drug imatinib mesylate (IM). Prosurvival genes that are preferentially expressed in CMLSCs compared with normal hematopoietic stem cells (HSCs) represent potential therapeutic targ...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ma, Leyuan, Pak, Magnolia L., Ou, Jianhong, Yu, Jun, St. Louis, Pamela, Shan, Yi, Hutchinson, Lloyd, Li, Shaoguang, Brehm, Michael A., Zhu, Lihua Julie, Green, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535024/
https://ncbi.nlm.nih.gov/pubmed/31068472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903550116
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