A Therapeutically Targetable Mechanism of BCR-ABL-Independent Imatinib Resistance in Chronic Myeloid Leukemia

Resistance to the BCR-ABL inhibitor imatinib mesylate (IM) poses a major problem for the treatment of chronic myeloid leukemia (CML). IM resistance often results from a secondary mutation in BCR-ABL that interferes with drug binding. However, in many instances there is no mutation in BCR-ABL, and th...

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Hauptverfasser: Ma, Leyuan, Shan, Yi, Bai, Robert, Xue, Liting, Eide, Christopher A., Ou, Jianhong, Zhu, Lihua J., Hutchinson, Lloyd, Cerny, Jan, Khoury, Hanna Jean, Sheng, Zhi, Druker, Brian J., Li, Shaoguang, Green, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162097/
https://ncbi.nlm.nih.gov/pubmed/25186176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3009073
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