Derivation of simian tropic HIV-1 infectious clone reveals virus adaptation to a new host

To replicate in a new host, lentiviruses must adapt to exploit required host factors and evade species-specific antiviral proteins. Understanding how host protein variation drives lentivirus adaptation allowed us to expand the host range of HIV-1 to pigtail macaques. We have previously derived a vir...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Schmidt, Fabian, Keele, Brandon F., Del Prete, Gregory Q., Voronin, Dennis, Fennessey, Christine M., Soll, Steven, Kane, Melissa, Raymond, Alice, Gifford, Robert J., KewalRamani, Vineet, Lifson, Jeffrey D., Bieniasz, Paul D., Hatziioannou, Theodora
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535013/
https://ncbi.nlm.nih.gov/pubmed/31048506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818059116
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