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Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi
Nonribosomal peptide synthetases (NRPSs) and NRPS-like enzymes have diverse functions in primary and secondary metabolisms. By using a structure-guided approach, we uncovered the function of a NRPS-like enzyme with unusual domain architecture, catalyzing two sequential two-electron reductions of gly...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6535007/ https://ncbi.nlm.nih.gov/pubmed/31061132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903282116 |
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