Simvastatin protects photoreceptors from oxidative stress induced by all‐trans‐retinal, through the up‐regulation of interphotoreceptor retinoid binding protein

BACKGROUND AND PURPOSE: Simvastatin is a 3‐hydroxy‐3‐methylglutaryl CoA reductase inhibitor with multiple targets and effects. It protects neurons in the brain, but its protective effects on photoreceptors are unclear. In this study, we evaluated the neuroprotective effect of simvastatin on photorec...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Zhang, Ting, Gillies, Mark, Wang, Ying, Shen, Weiyong, Bahrami, Bobak, Zeng, Shaoxue, Zhu, Meidong, Yao, Wenjuan, Zhou, Fanfan, Murray, Michael, Wang, Ke, Zhu, Ling
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534793/
https://ncbi.nlm.nih.gov/pubmed/30825184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14650
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