Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as biocatalyst for selective formation of drug metabolites. Hence, molecular and computational biologists have in the last two decades s...

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Bibliographic Details
Published in:PLoS One
Main Authors: Frydenvang, Karla, Verkade-Vreeker, Marlies C. A., Dohmen, Floor, Commandeur, Jan N. M., Rafiq, Maria, Mirza, Osman, Jørgensen, Flemming Steen, Geerke, Daan P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534296/
https://ncbi.nlm.nih.gov/pubmed/31125381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217292
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