Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha

Background: Thyroid hormones act in bone and cartilage via thyroid hormone receptor alpha (TRα). In the absence of triiodothyronine (T3), TRα interacts with co-repressors, including nuclear receptor co-repressor-1 (NCoR1), which recruit histone deacetylases (HDACs) and mediate transcriptional repres...

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Pubblicato in:Thyroid
Autori principali: Freudenthal, Bernard, Shetty, Samiksha, Butterfield, Natalie C., Logan, John G., Han, Cho Rong, Zhu, Xuguang, Astapova, Inna, Hollenberg, Anthony N., Cheng, Sheue-Yann, Bassett, J.H. Duncan, Williams, Graham R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc., publishers 2019
Soggetti:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533791/
https://ncbi.nlm.nih.gov/pubmed/30760120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2018.0399
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