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Molecular interplay between hyperactive mTOR signaling and Alzheimer’s disease neuropathology in the NS-Pten knockout mouse model
Dysregulation of the PI3K/Akt/mTOR signaling cascade has been associated with the pathology of neurodegenerative disorders, specifically Alzheimer’s disease (AD). Both in vivo models and post-mortem brain samples of individuals with AD have commonly shown hyperactivation of the pathway. In the prese...
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| Udgivet i: | Neuroreport |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533623/ https://ncbi.nlm.nih.gov/pubmed/29965873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0000000000001081 |
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