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Molecular interplay between hyperactive mTOR signaling and Alzheimer’s disease neuropathology in the NS-Pten knockout mouse model

Dysregulation of the PI3K/Akt/mTOR signaling cascade has been associated with the pathology of neurodegenerative disorders, specifically Alzheimer’s disease (AD). Both in vivo models and post-mortem brain samples of individuals with AD have commonly shown hyperactivation of the pathway. In the prese...

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Bibliografske podrobnosti
izdano v:Neuroreport
Main Authors: Hodges, Samantha L., Reynolds, Conner D., Smith, Gregory D., Jefferson, Taylor S., Nolan, Suzanne O., Lugo, Joaquin N.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533623/
https://ncbi.nlm.nih.gov/pubmed/29965873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0000000000001081
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