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Elucidation of the Differences in Cinobufotalin’s Pharmacokinetics Between Normal and Diethylnitrosamine-Injured Rats: The Role of P-Glycoprotein

Cinobufotalin is one of the major anti-tumor components isolated from toad venom and has been used in the clinical therapy of hepatocellular carcinoma (HCC), known as Cinobufacini injection. However, the pharmacokinetic (PK) behaviors of cinobufotalin in vivo with HCC are still unknown. Hence, we ha...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhang, Xiaojing, Liu, Tong, Zhang, Yidan, Liu, Fanye, Li, Haiying, Fang, Dong, Wang, Chaojie, Sun, Hua, Xie, Songqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533572/
https://ncbi.nlm.nih.gov/pubmed/31156437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00521
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