Metabolism of IMM-H004 and Its Pharmacokinetic-Pharmacodynamic Analysis in Cerebral Ischemia/Reperfusion Injured Rats

IMM-H004, a derivative of coumarin, is a promising candidate for the treatment of cerebral ischemia. The pharmacodynamic mechanisms of IMM-H004 are still under exploration. The present study was conducted to explore the pharmacoactive substances of IMM-H004 from the perspective of drug metabolism. F...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhang, Ziqian, Liu, Dandan, Jiang, Jianwei, Song, Xiuyun, Zou, Xiaowen, Chu, Shifeng, Xie, Kebo, Dai, Jungui, Chen, Naihong, Sheng, Li, Li, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584114/
https://ncbi.nlm.nih.gov/pubmed/31249524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00631
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