Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos

Precise genome editing is limited by the inefficiency of homology-directed repair (HDR) compared to the non-homologous end-joining (NHEJ) of double strand breaks (DSBs). The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 system generates precise, locus-specific DSBs that can...

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Udgivet i:Commun Biol
Main Authors: Aksoy, Yagiz A., Nguyen, David T., Chow, Sharron, Chung, Roger S., Guillemin, Gilles J., Cole, Nicholas J., Hesselson, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533270/
https://ncbi.nlm.nih.gov/pubmed/31149642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0444-0
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