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Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos
Precise genome editing is limited by the inefficiency of homology-directed repair (HDR) compared to the non-homologous end-joining (NHEJ) of double strand breaks (DSBs). The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 system generates precise, locus-specific DSBs that can...
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| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533270/ https://ncbi.nlm.nih.gov/pubmed/31149642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0444-0 |
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