Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage

Mammalian Sphingosine kinase 2 is the primary enzyme responsible for phosphorylating FTY720 to its active form, FTY720-P. Systemic FTY720 treatment confers significant protection to murine retinas from light- and disease-mediated photoreceptor cell death. It is not clear whether FTY720-P, FTY720, or...

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Publicat a:Sci Rep
Autors principals: Qi, Hui, Cole, Jerome, Grambergs, Richard C., Gillenwater, John R., Mondal, Koushik, Khanam, Sufiya, Dutta, Soma, Stiles, Megan, Proia, Richard L., Allegood, Jeremy, Mandal, Nawajes
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533254/
https://ncbi.nlm.nih.gov/pubmed/31123291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44047-z
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