Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are unclear. Furthermore, the necessity of NL docking...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Budaitis, Breane G, Jariwala, Shashank, Reinemann, Dana N, Schimert, Kristin I, Scarabelli, Guido, Grant, Barry J, Sept, David, Lang, Matthew J, Verhey, Kristen J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2019
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533058/
https://ncbi.nlm.nih.gov/pubmed/31084716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44146
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