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Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity
Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are unclear. Furthermore, the necessity of NL docking...
Guardat en:
| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533058/ https://ncbi.nlm.nih.gov/pubmed/31084716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44146 |
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