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Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes
Inflammasomes are multi-protein platforms that initiate innate immunity by recruitment and activation of Caspase-1. The NLRP1B inflammasome is activated upon direct cleavage by the anthrax lethal toxin protease. However, the mechanism by which cleavage results in NLRP1B activation is unknown. Here w...
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| Publicado en: | Science |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6532986/ https://ncbi.nlm.nih.gov/pubmed/30872533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau1330 |
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