Diverse viral proteases activate the NLRP1 inflammasome

The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains of NLRP1B and liberation of the bioactive C-termin...

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Udgivet i:eLife
Main Authors: Tsu, Brian V, Beierschmitt, Christopher, Ryan, Andrew P, Agarwal, Rimjhim, Mitchell, Patrick S, Daugherty, Matthew D
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Immunology and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857732/
https://ncbi.nlm.nih.gov/pubmed/33410748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60609
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