A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

Infections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have severe side effects. Here, the trypanosome haptoglobin-haemoglobin receptor (HpHbR) has been exploited as a route of uptake for an antibody-dr...

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Detalles Bibliográficos
Publicado en:PLoS Negl Trop Dis
Main Authors: MacGregor, Paula, Gonzalez-Munoz, Andrea L., Jobe, Fatoumatta, Taylor, Martin C., Rust, Steven, Sandercock, Alan M., Macleod, Olivia J. S., Van Bocxlaer, Katrien, Francisco, Amanda F., D’Hooge, Francois, Tiberghien, Arnaud, Barry, Conor S., Howard, Philip, Higgins, Matthew K., Vaughan, Tristan J., Minter, Ralph, Carrington, Mark
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532856/
https://ncbi.nlm.nih.gov/pubmed/31120889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007373
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