GWAS-driven Gene-set Analyses, Genetic and Functional Follow-up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse

BACKGROUND: Mitral valve prolapse (MVP) is a common heart valve disease, the most frequent indication for valve repair and/or replacement. MVP is characterized by excess extracellular matrix secretion and cellular disorganization which leads to bulky valves that are unable to co-apt correctly during...

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Publicado no:Circ Genom Precis Med
Main Authors: Yu, Mengyao, Georges, Adrien, Tucker, Nathan R., Kyryachenko, Sergiy, Toomer, Katelyn, Schott, Jean-Jacques, Delling, Francesca N., Fernandez-Friera, Leticia, Solis, Jorge, Ellinor, Patrick T., Levine, Robert A., Slaugenhaupt, Susan A., Hagège, Albert A., Dina, Christian, Jeunemaitre, Xavier, Milan, David J., Norris, Russell A., Bouatia-Naji, Nabila
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532425/
https://ncbi.nlm.nih.gov/pubmed/31112420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.119.002497
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