Primary cilia defects causing mitral valve prolapse

Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for mitral valve surgery. MVP can cause arrhythmias, heart failure, and sudden cardiac death, and to date, the causes of this disease are poorly understood. We now demonstrate that defects in primary cilia genes and...

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發表在:Sci Transl Med
Main Authors: Toomer, Katelynn A., Yu, Mengyao, Fulmer, Diana, Guo, Lilong, Moore, Kelsey S., Moore, Reece, Drayton, Ka’la D., Glover, Janiece, Peterson, Neal, Ramos-Ortiz, Sandra, Drohan, Alex, Catching, Breiona J., Stairley, Rebecca, Wessels, Andy, Lipschutz, Joshua H., Delling, Francesca N., Jeunemaitre, Xavier, Dina, Christian, Collins, Ryan L., Brand, Harrison, Talkowski, Michael E., del Monte, Federica, Mukherjee, Rupak, Awgulewitsch, Alexander, Body, Simon, Hardiman, Gary, Hazard, E. Starr, da Silveira, Willian A., Wang, Baolin, Leyne, Maire, Durst, Ronen, Markwald, Roger R., Le Scouarnec, Solena, Hagege, Albert, Le Tourneau, Thierry, Kohl, Peter, Rog-Zielinska, Eva A., Ellinor, Patrick T., Levine, Robert A., Milan, David J., Schott, Jean-Jacques, Bouatia-Naji, Nabila, Slaugenhaupt, Susan A., Norris, Russell A.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331025/
https://ncbi.nlm.nih.gov/pubmed/31118289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax0290
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