A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation

BACKGROUND: Epidermal growth factor receptor (EGFR) and epidermal growth factor receptor pathway substrate 8 (Eps8) have been widely reported to be expressed in various tumors. Eps8 is an important active kinase substrate of EGFR that directly binds to the juxtamembrane (JXM) domain of EGFR to form...

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Bibliografiset tiedot
Julkaisussa:J Exp Clin Cancer Res
Päätekijät: Li, Meifang, Yang, Jilong, Zhang, Lenghe, Tu, Sanfang, Zhou, Xuan, Tan, Ze, Zhou, Weijun, He, Yanjie, Li, Yuhua
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2019
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532146/
https://ncbi.nlm.nih.gov/pubmed/31118055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1207-y
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