A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation

BACKGROUND: Epidermal growth factor receptor (EGFR) and epidermal growth factor receptor pathway substrate 8 (Eps8) have been widely reported to be expressed in various tumors. Eps8 is an important active kinase substrate of EGFR that directly binds to the juxtamembrane (JXM) domain of EGFR to form...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Clin Cancer Res
Egile Nagusiak: Li, Meifang, Yang, Jilong, Zhang, Lenghe, Tu, Sanfang, Zhou, Xuan, Tan, Ze, Zhou, Weijun, He, Yanjie, Li, Yuhua
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2019
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532146/
https://ncbi.nlm.nih.gov/pubmed/31118055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1207-y
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