A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation

BACKGROUND: Epidermal growth factor receptor (EGFR) and epidermal growth factor receptor pathway substrate 8 (Eps8) have been widely reported to be expressed in various tumors. Eps8 is an important active kinase substrate of EGFR that directly binds to the juxtamembrane (JXM) domain of EGFR to form...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Li, Meifang, Yang, Jilong, Zhang, Lenghe, Tu, Sanfang, Zhou, Xuan, Tan, Ze, Zhou, Weijun, He, Yanjie, Li, Yuhua
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532146/
https://ncbi.nlm.nih.gov/pubmed/31118055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1207-y
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